I've used this tactic: You have something serious to say, but aren't sure if this is the venue for such a sober point. So, you use humor to buffer the seriousness.
In Chris Pratt's case last night, the humor was definitely bathroom humor, but I love what he said in his points between the poo.
[It was pointed out to me by a listener this morning that perhaps Pratt's point #7 was the hamburger referenced in #4 to help swallow the medicine that was points #6, 8, and 9. (That's clear enough, right?)]